Cajun Chicken Alfredo Pasta

Featured in: Quick Weeknight Flames

This dish features juicy chicken breasts seasoned with Cajun spices, sautéed to golden perfection. Fettuccine pasta is cooked al dente and combined with a creamy Velveeta cheese sauce enriched with garlic, butter, and Parmesan. The sauce is smooth and flavorful, with a touch of cayenne for heat if desired. Garnished with fresh parsley and extra Parmesan, this meal blends Southern spice with Italian-inspired pasta for a satisfying, easy-to-make dinner.

Updated on Sun, 23 Nov 2025 13:52:00 GMT
Tender Cajun chicken nestled atop creamy Cajun Chicken Alfredo Fettuccine, ready to be enjoyed. Save
Tender Cajun chicken nestled atop creamy Cajun Chicken Alfredo Fettuccine, ready to be enjoyed. | fireandbites.com

A creamy, spicy pasta dish featuring tender Cajun-seasoned chicken, rich Velveeta cheese sauce, and perfectly cooked fettuccine—comfort food with a Southern twist.

This recipe quickly became a family favorite after I made it for a weeknight dinner everyone enjoyed.

Ingredients

  • Chicken: 2 large boneless skinless chicken breasts 1 ½ tablespoons Cajun seasoning 1 tablespoon olive oil
  • Pasta: 12 oz (340 g) fettuccine pasta
  • Sauce: 2 tablespoons unsalted butter 2 cloves garlic minced 1 cup (240 ml) heavy cream 8 oz (225 g) Velveeta cheese cubed ½ cup (50 g) grated Parmesan cheese ½ teaspoon black pepper ¼ teaspoon cayenne pepper (optional for extra heat) Salt to taste
  • Garnish: 2 tablespoons fresh parsley chopped Extra grated Parmesan cheese (optional)

Instructions

Step 1:
Bring a large pot of salted water to a boil. Cook the fettuccine according to package instructions until al dente. Drain and set aside reserving ½ cup pasta water.
Step 2:
While the pasta cooks pat chicken breasts dry. Rub both sides with Cajun seasoning.
Step 3:
In a large skillet heat olive oil over medium-high heat. Add chicken and cook 5 6 minutes per side or until golden and cooked through (internal temperature 165°F/74°C). Remove chicken let rest 5 minutes then slice thinly.
Step 4:
In the same skillet reduce heat to medium. Add butter and garlic sauté 1 minute until fragrant.
Step 5:
Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes stirring often until melted and smooth.
Step 6:
Add Parmesan cheese black pepper and cayenne pepper (if using). Stir until fully combined and creamy. If sauce is too thick add reserved pasta water a little at a time.
Step 7:
Toss cooked fettuccine in the sauce until well coated.
Step 8:
Divide pasta among plates. Top with sliced Cajun chicken. Garnish with parsley and extra Parmesan if desired.
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Making this dish created many happy moments around our family table as everyone shared seconds and stories.

Notes

Adjust Cajun seasoning for more or less heat. Substitute rotisserie chicken for a quicker version. Add sautéed bell peppers or mushrooms for extra flavor and color. Pairs well with a crisp green salad and a chilled Chardonnay.

Required Tools

Large pot Large skillet Knife and cutting board Tongs or pasta fork Measuring cups and spoons

Allergen Information

Contains milk/dairy (Velveeta Parmesan cream butter) Contains wheat (fettuccine) Contains chicken Those with allergies should check ingredient labels for hidden allergens.

Rich, cheesy Velveeta sauce coats the fettuccine in this flavorful Cajun Chicken Alfredo. Save
Rich, cheesy Velveeta sauce coats the fettuccine in this flavorful Cajun Chicken Alfredo. | fireandbites.com

This Cajun Chicken Alfredo is sure to become a new comfort food favorite thanks to its bold flavors and creamy texture.

Common Questions

What cut of chicken works best here?

Boneless, skinless chicken breasts are ideal as they cook evenly and remain tender when seasoned and sautéed.

Can I adjust the spiciness level?

Yes, you can modify the Cajun seasoning amount or omit cayenne pepper for a milder flavor.

How do I make the sauce creamy without lumps?

Slowly melt Velveeta cheese into warm cream while stirring constantly to achieve a smooth, rich sauce.

Is there a way to make this dish quicker?

Using pre-cooked or rotisserie chicken reduces prep time without compromising flavor.

What sides pair well with this dish?

A crisp green salad or steamed vegetables balance the richness and complement the Southern-inspired flavors.

Cajun Chicken Alfredo Pasta

Spicy Cajun chicken with rich Velveeta sauce and fettuccine delivers Southern-inspired comfort.

Setup Duration
15 min
Time at Heat
25 min
Complete Duration
40 min
Created by Logan Hayes


Skill Level Easy

Cultural Background American (Cajun-inspired)

Output 4 Portion Count

Special Diet Info None specified

What You'll Need

Chicken

01 2 large boneless, skinless chicken breasts
02 1 1/2 tablespoons Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine pasta

Sauce

01 2 tablespoons unsalted butter
02 2 cloves garlic, minced
03 1 cup heavy cream
04 8 ounces Velveeta cheese, cubed
05 1/2 cup grated Parmesan cheese
06 1/2 teaspoon black pepper
07 1/4 teaspoon cayenne pepper (optional)
08 Salt, to taste

Garnish

01 2 tablespoons fresh parsley, chopped
02 Extra grated Parmesan cheese (optional)

Method Steps

Phase 01

Cook Pasta: Bring a large pot of salted water to a boil. Cook fettuccine until al dente according to package directions. Drain, reserving 1/2 cup pasta water, and set pasta aside.

Phase 02

Prepare Chicken: Pat chicken breasts dry and rub both sides with Cajun seasoning.

Phase 03

Sear Chicken: Heat olive oil in a large skillet over medium-high heat. Cook chicken 5 to 6 minutes per side until golden and cooked through (internal temperature 165°F). Remove and let rest 5 minutes before slicing thinly.

Phase 04

Sauté Garlic: Reduce heat to medium, add butter and garlic to the skillet, and sauté for 1 minute until fragrant.

Phase 05

Make Sauce: Stir in heavy cream and bring to a gentle simmer. Add Velveeta cubes, stirring frequently until melted and smooth.

Phase 06

Combine Sauce Ingredients: Add Parmesan, black pepper, and optional cayenne pepper. Stir until fully incorporated and creamy. If sauce is too thick, gradually add reserved pasta water to achieve desired consistency.

Phase 07

Toss Pasta in Sauce: Add cooked fettuccine to the sauce and toss well to coat evenly.

Phase 08

Plate and Garnish: Divide pasta among plates, top with sliced Cajun chicken, and garnish with chopped parsley and additional Parmesan if desired.

Kitchen Tools Needed

  • Large pot
  • Large skillet
  • Knife and cutting board
  • Tongs or pasta fork
  • Measuring cups and spoons

Allergy Details

Always review ingredients individually for potential allergens and seek professional medical guidance if uncertain.
  • Contains dairy (Velveeta, Parmesan, cream, butter)
  • Contains wheat (fettuccine pasta)
  • Contains poultry (chicken)

Dietary Information (Single Portion)

Values shown are estimates only - please consult healthcare providers for specific dietary advice.
  • Energy Content: 670
  • Fats: 32 g
  • Carbohydrates: 57 g
  • Proteins: 41 g